The effect of 7-oxo-DHEA acetate on memory in young and old C57BL/6 mice
Identifieur interne : 009E13 ( Main/Exploration ); précédent : 009E12; suivant : 009E14The effect of 7-oxo-DHEA acetate on memory in young and old C57BL/6 mice
Auteurs : Jennifer Shi [États-Unis] ; Stacy Schulze [États-Unis] ; Henry A. Lardy [États-Unis]Source :
- Steroids [ 0039-128X ] ; 2000.
English descriptors
- KwdEn :
- Teeft :
- Acetate, Acetate group, Acetate treatment, Acquisition training, Amnesic effect, Behav brain, Biol chem, Biological activity, Cholinergic, Cholinergic function, Cholinergic pathways, Cholinergic receptor blockade, Control group, Dehydroepiandrosterone, Dehydroepiandrosterone sulfate, Dhea, Diabetic mice, Distal cues, Elsevier science, Gabaa receptor, Lardy, Last acquisition training trial, Last training trial, Least square, Male mice, Memory retention, Memory retention time, Morris water maze, Morris water task, Mouse, Nervous system, Neurosteroids, Normal mice, Original scale, Overall treatment effect, Potent allosteric inhibitor, Proc, Proc natl acad, Rabbit liver slices, Randomized design, Receptor, Retention testing, Retention testing time, Scopolamine, Second experiment, Spatial memory, Standard errors, Statistical analysis, Steroid, Steroid biochem, Therapeutic effects, Thermogenic enzymes, Training time, Training trial, Training trials, Treatment groups, Week time, Young mice.
Abstract
Abstract: 7-Oxo-dehydroepiandrosterone, which can be formed from dehydroepiandrosterone (DHEA) by several mammalian tissues, is more effective than its parent steroid as an inducer of thermogenic enzymes when administered to rats. Using the Morris water maze procedure, we tested DHEA and its 7-oxo-derivative for their ability to reverse the memory abolition induced by scopolamine in young C57BL/6 mice, and for their effect on memory in old mice. A single dose of 7-oxo-DHEA-acetate at 24 mg/kg b.w. completely reversed the impairment caused by 1 mg of scopolamine per kg b.w. (P < 0.001). DHEA (20 mg/kg) was also effective (P < 0.01). In old mice given the same single doses followed by feeding 0.05% of the respective steroid in the diet, memory of the water maze training was retained through a four week test period in mice receiving 7-oxo-DHEA-acetate (P < 0.05) but not in the control or DHEA-treated groups. When old mice were not tested until five weeks after being trained 7-oxo-DHEA exerted a slight, but statistically insignificant, improvement in memory retention. The possible effect of 7-oxo-DHEA in human memory problems deserves investigation.
Url:
DOI: 10.1016/S0039-128X(99)00094-X
Affiliations:
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Lardy</name><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Institute for Enzyme Research, University of Wisconsin–Madison, Madison, WI 53705-4098</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Steroids</title><title level="j" type="abbrev">STE</title><idno type="ISSN">0039-128X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">65</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="124">124</biblScope><biblScope unit="page" to="129">129</biblScope></imprint><idno type="ISSN">0039-128X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0039-128X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>7-Oxo-dehydroepiandrosterone</term><term>Memory, Mice</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acetate</term><term>Acetate group</term><term>Acetate treatment</term><term>Acquisition training</term><term>Amnesic effect</term><term>Behav brain</term><term>Biol chem</term><term>Biological activity</term><term>Cholinergic</term><term>Cholinergic function</term><term>Cholinergic pathways</term><term>Cholinergic receptor blockade</term><term>Control group</term><term>Dehydroepiandrosterone</term><term>Dehydroepiandrosterone sulfate</term><term>Dhea</term><term>Diabetic mice</term><term>Distal cues</term><term>Elsevier science</term><term>Gabaa receptor</term><term>Lardy</term><term>Last acquisition training trial</term><term>Last training trial</term><term>Least square</term><term>Male mice</term><term>Memory retention</term><term>Memory retention time</term><term>Morris water maze</term><term>Morris water task</term><term>Mouse</term><term>Nervous system</term><term>Neurosteroids</term><term>Normal mice</term><term>Original scale</term><term>Overall treatment effect</term><term>Potent allosteric inhibitor</term><term>Proc</term><term>Proc natl acad</term><term>Rabbit liver slices</term><term>Randomized design</term><term>Receptor</term><term>Retention testing</term><term>Retention testing time</term><term>Scopolamine</term><term>Second experiment</term><term>Spatial memory</term><term>Standard errors</term><term>Statistical analysis</term><term>Steroid</term><term>Steroid biochem</term><term>Therapeutic effects</term><term>Thermogenic enzymes</term><term>Training time</term><term>Training trial</term><term>Training trials</term><term>Treatment groups</term><term>Week time</term><term>Young mice</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: 7-Oxo-dehydroepiandrosterone, which can be formed from dehydroepiandrosterone (DHEA) by several mammalian tissues, is more effective than its parent steroid as an inducer of thermogenic enzymes when administered to rats. Using the Morris water maze procedure, we tested DHEA and its 7-oxo-derivative for their ability to reverse the memory abolition induced by scopolamine in young C57BL/6 mice, and for their effect on memory in old mice. A single dose of 7-oxo-DHEA-acetate at 24 mg/kg b.w. completely reversed the impairment caused by 1 mg of scopolamine per kg b.w. (P < 0.001). DHEA (20 mg/kg) was also effective (P < 0.01). In old mice given the same single doses followed by feeding 0.05% of the respective steroid in the diet, memory of the water maze training was retained through a four week test period in mice receiving 7-oxo-DHEA-acetate (P < 0.05) but not in the control or DHEA-treated groups. When old mice were not tested until five weeks after being trained 7-oxo-DHEA exerted a slight, but statistically insignificant, improvement in memory retention. The possible effect of 7-oxo-DHEA in human memory problems deserves investigation.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Wisconsin</li></region></list><tree><country name="États-Unis"><region name="Wisconsin"><name sortKey="Shi, Jennifer" sort="Shi, Jennifer" uniqKey="Shi J" first="Jennifer" last="Shi">Jennifer Shi</name></region><name sortKey="Lardy, Henry A" sort="Lardy, Henry A" uniqKey="Lardy H" first="Henry A" last="Lardy">Henry A. Lardy</name><name sortKey="Lardy, Henry A" sort="Lardy, Henry A" uniqKey="Lardy H" first="Henry A" last="Lardy">Henry A. Lardy</name><name sortKey="Schulze, Stacy" sort="Schulze, Stacy" uniqKey="Schulze S" first="Stacy" last="Schulze">Stacy Schulze</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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